最新临床结果：间充质干细胞有效减缓SMA疾病进展，显著延长生存期( 二 ) _健康小知识

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相信随着科学研究和临床试验的广泛开展，间充质干细胞治疗有望成为脊髓性肌萎缩症的新一代治疗方案，为更多尚在襁褓就被判处死刑的孩子带来生命的曙光。
参考文献
[1]Mohseni,R.,Hamidieh,A.A.,Shoae-Hassani,A.etal.Anopen-labelphase1clinicaltrialoftheallogeneicsidepopulationadipose-derivedmesenchymalstemcellsinSMAtype1patients.NeurolSci(2021).https://doi.org/10.1007/s10072-021-05291-2
[2]KeinathMC,PriorDE,PriorTW(2021)Spinalmuscularatrophy:mutations,testing,andclinicalrelevance.ApplClinGenet25(14):11–25.https://doi.org/10.2147/TACG.S239603
[3]LiT,MaH,MaH,MaZ,QiangL,YangZ,YangX,ZhouX,DaiK,WangJ(2019)Mussel-inspirednanostructurespotentiatetheimmunomodulatorypropertiesandangiogenesisofmesenchymalstemcells.ACSApplMaterInterfaces11(19):17134–17146.https://doi.org/10.1021/acsami.8b22017
[4]UrrutiaDN,CaviedesP,MardonesR,MinguellJJ,Vega-LetterAM,JofreCM(2019)Comparativestudyoftheneuraldifferentiationcapacityofmesenchymalstromalcellsfromdifferenttissuesources:anapproachfortheiruseinneuralregenerationtherapies.PLoSOne14(3):e0213032.https://doi.org/10.1371/journal.pone.0213032
[5]JinJ,ShiY,GongJ,ZhaoL,LiY,HeQ,HuangH(2019)Exosomesecretedfromadipose-derivedstemcellsattenuatesdiabeticnephropathybypromotingautophagyfluxandinhibitingapoptosisinpodocyte.StemCellResTher10(1):95.https://doi.org/10.1186/s13287-019-1177-1
[6]FengM,LiuC,XiaY,etal.RestorationofSMNexpressioninmesenchymalstemcellsderivedfromgene-targetedpatient-specificiPSCs.JMolHistol.2018;49(1):27-37.https://doi.org/10.1007/s10735-017-9744-1